Fire has razed down tenth floor of the Job 600 building which serves as offices of Members of Parliament (MPs).
The MPs who were working in their offices when the fire started rushed downstairs to avoid being hurt.
No death or injuries have been recorded, but items worth millions of Ghana cedis have been lost in the inferno.
Firefighters are still struggling to quench the fire which seems to be spreading other floors.
The cause of fire is unknown.